Department of Biochemistry · School of Medicine
The molecule behind every essential pathway of life.
A multidisciplinary group studying the dynamic networks of RNA biology — from tRNA biogenesis and riboswitches to non-coding RNAs and mRNA turnover in human disease.
80+
Publications since 1995
12
Group Members
3
Core Research Streams
6
Funding Bodies
Three streams, one integrated approach.
tRNA
tRNA & translation
Biogenesis, aminoacylation and signalling; T-box riboswitches as novel antibiotic targets in pathogens.
ncRNAs
Non-coding RNAs
Novel miRNAs and tRNA-derived fragments across human disease models and melanoma plasticity.
mRNA
mRNA turnover
Characterising essential enzymes that regulate mRNA stability and cap-dependent translation in cancer.
What the group works on
RNA holds a central role as an essential modulator of a wide network of reactions in all domains of life. High-throughput methods keep uncovering new roles, and the group’s work spans six connected areas.
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Dynamic networks of tRNA biogenesis, aminoacylation and signalling in human
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The role of rRNA in antibiotic resistance
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Identification of novel miRNAs and tRFs in various human disease models
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Regulation of multiple pathways by tRNA-dependent riboswitches (T-boxes) in pathogens
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Characterisation of essential enzymes with a role in mRNA turnover
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Studies on RNA-related proteins that modulate its regulatory role
Recent work
- A riboswitch-driven era of new antibacterials. Giarimoglou N., Kouvela A., Maniatis A., Papakyriakou A., Zhang J., Stamatopoulou V. & Stathopoulos C. Antibiotics (Basel) 11:1243 2022
- NMR analysis suggests synergy between the RRM2 and the carboxy-terminal segment of human La protein in the recognition and interaction with HCV IRES. Argyriou A.I., Machaliotis G.A., Makrynitsa G.I., Kaliatsi E.G., Stathopoulos C. & Spyroulias G.A. Int J Mol Sci 24:2572 2023
- Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response. Grafanaki K., Grammatikakis I., Ghosh A., Gopalan V., Olgun G., Liu H., Kyriakopoulos G.C., Skeparnias I., Georgiou S., Stathopoulos C., Hannenhalli S., Merlino G., Marie K.L. & Day C.P. Pharmacol Ther 248:108466 2023
Work with the group
We host undergraduate, MSc, PhD and postdoctoral researchers working across RNA biology.